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Image Search Results
Journal: JACC: Basic to Translational Science
Article Title: Methylated PIH1D1 as a Heart-Specific Biomarker for Anthracycline-Induced Cardiac Remodeling in Breast Cancer Patients
doi: 10.1016/j.jacbts.2026.101510
Figure Lengend Snippet: Higher Elevated Troponin-I (High-Sensitivity Cardiac Troponin I) Levels Are Associated With Reduced Ejection Fraction (A) High-sensitivity cardiac troponin I (hs-cTnI) and (B) B-type natriuretic peptide (BNP) levels were measured at baseline (pretreatment) and various post-treatment (3, 6, 12, and 24 months). The red line represents mean values at each time point; fold changes were calculated relative to the baseline. Individual patient trajectories are shown as gray lines, with the mean fold change highlighted in red. Longitudinal changes relative to baseline were analyzed using linear mixed-effects models accounting for within-patient correlation, with baseline-referenced post hoc contrasts adjusted for multiple comparisons. Fold changes of (C) LVESV, (D) LVEDV, (E) LVEF, and (F) LVS′ were relative to baseline over time points (3, 6, 12, 24, 30, and 36 months) in patients stratified by high-sensitivity cardiac troponin I levels: troponin ≥0.028 (red line) and troponin <0.028 (blue line). Each point represents an individual patient, with means shown by the lines for each group, and shaded areas represent the 95% CI. Between-group differences over time were analyzed using repeated-measures models accounting for within-patient correlation, with P values adjusted for multiple comparisons. Statistical significance is indicated by asterisks. Statistical significance is indicated by asterisks (∗ P < 0.05, ∗∗ P < 0.01, ∗∗∗ P < 0.001). Abbreviations as in .
Article Snippet: High-sensitivity cardiac troponin I (hs-cTnI) and BNP levels were measured using chemiluminescent microparticle immunoassays on the Abbott Architect platform (
Techniques: